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75567-37-2 - Ingenol 3-angelate, 98% - J60601 - Alfa Aesar

J60601 Ingenol 3-angelate, 98%

CAS Number
75567-37-2
Synonyms

Size Price ($) Quantity Availability
1mg 262.00
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Ingenol 3-angelate, 98%

MDL
MFCD07784504

Chemical Properties

Formula
C25H34O6
Formula Weight
348.40
Form
Powder
Solubility
Soluble in 100% ethanol, DMSO, dichloromethane, and methanol. Insoluble in water.

Applications

Ingenol 3-Angelate is used as a PKC activator, anticancer, and immunostimulant compound. It is also used to exhibits antileukemic activity, induces nuclear translocation of PKCδ, and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C

Literature References

Kedei et al. Characterization of the interaction of ingenol-3-angelate with protein kinase C. Cancer Res. 2004, 64, (9), 3243-55.

Hampson et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood . 2005, 106, (4), 1362-8.

Other References

Harmonized Tariff Code
2916.19
TSCA
No

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