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15291-77-7 - Ginkgolide B - BN-52021 - J60646 - Alfa Aesar

J60646 Ginkgolide B

CAS Number
15291-77-7
Synonyms
BN-52021

Size Price ($) Quantity Availability
10mg 77.80
50mg 268.00
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Ginkgolide B

MDL
MFCD05662347

Chemical Properties

Formula
C20H24O10
Formula Weight
424.40
Form
Powder
Solubility
Soluble in DMSO. Slightly soluble in water and ethanol

Applications

Ginkgolide B is used as a potent PAF-R antagonist. Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally, this compound has been reported to inhibit neutrophil degranulation in vitro. Inhibits superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Literature References

Desquand et al. Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 1986, 127 ,(1-2), 83-95.

Foldes-Filep et al. Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 1987, 148,(3), 1412-7.

Other References

Merck
14,4426
Harmonized Tariff Code
2932.20
TSCA
No

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