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13957-31-8 - 4-Thiouridine, 98+% - J60679 - Alfa Aesar

J60679 4-Thiouridine, 98+%

CAS Number
13957-31-8
Synonyms

Size Price ($) Quantity Availability
100mg 393.00
250mg 575.00
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4-Thiouridine, 98+%

MDL
MFCD00006538
EINECS
237-735-3

Chemical Properties

Formula
C9H12N2O5S
Formula Weight
260.27
Form
Crystalline
Solubility
Soluble in water (20 mg/ml), and methanol (10 mg/ml).

Applications

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, heat.

Literature References

A. Favre,; M. Yaniv,; A.M. Michels.The photochemistry of 4-thiouridine in escherichia coli t-RNAİVal. Biochemical and Biophysical Research Communications. 1969, 37 (2), 266-271.

L. Aravind,; Eugene V. Koonin.THUMP - a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. Trends in biochemical science. 2001, 26 (4) ,215-217.

Other References

Harmonized Tariff Code
2934.99
TSCA
No

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