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961-07-9 - 2'-Deoxyguanosine - J60741 - Alfa Aesar

J60741 2'-Deoxyguanosine

CAS Number
961-07-9
Synonyms

Size Price ($) Quantity Availability
1g 64.27
5g 100.00
10g 231.75
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2'-Deoxyguanosine

MDL
MFCD00080300
EINECS
213-505-8

Chemical Properties

Formula
C10H13N5O4
Formula Weight
267.25
Form
Crystalline powder
Solubility
Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.

Applications

Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Kasper Broedbaek et. al. Urinary 8-oxo-7,8-dihydro-2?-deoxyguanosine as a biomarker in type 2 diabetes. Free Radical Biology and Medicine. 2011, 51 (8), 1473-1479.

Aaron M Fleming et. al. Copper/H2O2-mediated oxidation of 2'-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts.. Journal of Organic Chemistry. 2011, 76 (19), 7953-7963.

Other References

Harmonized Tariff Code
2934.99
TSCA
Yes

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