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105628-07-7 - Fasudil monohydrochloride, 99+% - HA-1077 hydrochloride - Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride - J60751 - Alfa Aesar

J60751 Fasudil monohydrochloride, 99+%

CAS Number
105628-07-7
Synonyms
HA-1077 hydrochloride
Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride

Size Price ($) Quantity Availability
250mg 157.41
1g 188.49
500mg 220.52
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Fasudil monohydrochloride, 99+%

MDL
MFCD00943198

Chemical Properties

Formula
C14H17N3O2S•HCl
Formula Weight
327.83
Form
Powder
Solubility
Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.

Applications

Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration.

Notes

Incompatible with acids, bases and oxidizing agents.

Literature References

Gupta, N.; Patel, B.; Ahsan, F. Nano-Engineered Erythrocyte Ghosts as Inhalational Carriers for Delivery of Fasudil: Preparation and Characterization. Pharm. Res. 2014, 31 (6), 1553-1565.

Tang, A. T.; Campbell, W. B.; Nithipatikom, K. ROCK1 feedback regulation of the upstream small GTPase RhoA. Cell. Signalling 2012, 24 (7), 1375-1380.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3942
Harmonized Tariff Code
2935.00
TSCA
No
RTECS
HM4031166

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