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Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized to synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Shi, L.; Liang, L.; Wang, F.; Ma, J.; Sun, J. Polycondensation of guanidine hydrochloride into a graphitic carbon nitride semiconductor with a large surface area as a visible light photocatalyst. Catal. Sci. Tech. 2014, 4 (9), 3235-3243.
Dhondge, S. S.; Shende, P. H.; Paliwal, L. J.; Deshmukh, D. W. Volumetric and acoustic study of aqueous binary mixtures of quinine hydrochloride, guanidine hydrochloride and quinic acid at different temperatures. J. Chem. Thermodyn. 2015, 81, 34-43.
Hazard Statements: H302-H315-H319
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P280a-P305+P351+P338-P301+P312a-P321-P332+P313-P501a
Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.