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Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized to synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Shi, L.; Liang, L.; Wang, F.; Ma, J.; Sun, J. Polycondensation of guanidine hydrochloride into a graphitic carbon nitride semiconductor with a large surface area as a visible light photocatalyst. Catal. Sci. Tech. 2014, 4 (9), 3235-3243.
Dhondge, S. S.; Shende, P. H.; Paliwal, L. J.; Deshmukh, D. W. Volumetric and acoustic study of aqueous binary mixtures of quinine hydrochloride, guanidine hydrochloride and quinic acid at different temperatures. J. Chem. Thermodyn. 2015, 81, 34-43.
Hazard Statements: H302-H315-H319-H332-H500
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May form combustible dust concentrations in air
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant