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124182-57-6 - CGS 21680 hydrochloride, 99% - J60793 - Alfa Aesar

J60793 CGS 21680 hydrochloride, 99%

CAS Number
124182-57-6
Synonyms

Size Price ($) Quantity Availability
5mg 191.70
10mg 303.30
50mg 1314.00
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CGS 21680 hydrochloride, 99%

MDL
MFCD11045878

Chemical Properties

Formula
C23H29N7O6•HCl
Formula Weight
535.98
Form
Solid
Solubility
Soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

Applications

CGS 21680 hydrochloride is currently used in research in studying neuronal transmission, also in respiration. CGS 21680 is commonly used to study the actions of the adenosine A2A receptor in cells and tissues. CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. CGS 21680C effectively increases coronary flow with an ED25 value of 1.8 nM. In hippocampal slices, CGS 21680 apis weak agonist on pre- and postsynaptic measures of electrophysiologicaJ activity.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Cheng, M.K.,; Doumad, A.B., Jiang, H., et al. . Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat prelomerular microvessels (PGMV) via A2A receptors. . Br J Pharmacol . 2004, 141 441-448 .

Phillis,J.W.. The selective adenosine A2 receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity.. Brain Res.. 1990 , 509 328-330.

Other References

Harmonized Tariff Code
2934.99
TSCA
No

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