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39562-70-4 - Nitrendipine - J60841 - Alfa Aesar

J60841 Nitrendipine

CAS Number
39562-70-4
Synonyms

Size Price ($) Quantity Availability
100mg 56.01
500mg 234.90
1g 543.00
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Nitrendipine

MDL
MFCD00082255
EINECS
254-513-1

Chemical Properties

Formula
C18H20N2O6
Formula Weight
360.36
Form
Powder
Solubility
Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.

Applications

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

X Chen et. al.Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry.. Biomedical Chromatography. 2001, 15 (8), 518-524 .

J Muntwyler and F Follath.Calcium channel blockers in treatment of hypertension.. Progress in Cardiovascular Diseases. 2001, 44 (3), 207-216.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P261-P280-P264-P270-P304+P340-P301+P312-P312-P363-P322-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific measures (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6576
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
US5653000

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