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J60841 Nitrendipine

CAS Number
39562-70-4
Synonyms

Stock No. Size Price ($) Quantity Availability
J60841-MC 100mg 155.00
J60841-ME 500mg 309.00
J60841-03 1g 506.00
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Nitrendipine

MDL
MFCD00082255
EINECS
254-513-1

Chemical Properties

Formula
C18H20N2O6
Formula Weight
360.36
Form
Powder
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.

Applications

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

X Chen et. al.Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry.. Biomedical Chromatography. 2001, 15 (8), 518-524 .

J Muntwyler and F Follath.Calcium channel blockers in treatment of hypertension.. Progress in Cardiovascular Diseases. 2001, 44 (3), 207-216.

GHS Hazard and Precautionary Statements

Hazard Statements: H302+H312+H332

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P312-P330-P363-P501c

Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,6576
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
US5653000

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