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39562-70-4 - Nitrendipine - J60841 - Alfa Aesar

J60841 Nitrendipine

CAS Number
39562-70-4
Synonyms

Size Price ($) Quantity Availability
100mg 163.00
500mg 325.00
1g 532.00
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Nitrendipine

MDL
MFCD00082255
EINECS
254-513-1

Chemical Properties

Formula
C18H20N2O6
Formula Weight
360.36
Form
Powder
Solubility
Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.

Applications

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

X Chen et. al.Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry.. Biomedical Chromatography. 2001, 15 (8), 518-524 .

J Muntwyler and F Follath.Calcium channel blockers in treatment of hypertension.. Progress in Cardiovascular Diseases. 2001, 44 (3), 207-216.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H332

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P260u-P201-P280h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/clothing. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6576
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
US5653000

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