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4474-91-3 - Angiotensin II (human) - H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH acetate salt - J60866 - Alfa Aesar

J60866 Angiotensin II (human)

CAS Number
4474-91-3
Synonyms
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH acetate salt

Size Price ($) Quantity Availability
5mg 48.41
25mg 165.83
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Angiotensin II (human)

MDL
MFCD00133092

Chemical Properties

Formula
C50H71N13O12
Formula Weight
1046.19
Form
Powder
Solubility
Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).

Applications

Ang II stimulates angiogenesis and increases microvessel density. In addition, the renin-angiotensin and nitric oxide-generating systems appear to interract in the regulation of cardiovascular function. Angiotensin (Ang) II is a peptide which plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity. It also increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons and activates JAK2 in smooth muscle cells.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20°C. keep away from Strong acids, Strong bases .

Literature References

Caroline Cheng et. Al. Angiotensin II (ATII)-mediated hypertension increases the risk for acute coronary events, which may be caused by augmented collagen degradation. Interstitial fibers of collagen type I in the plaque can be degraded by MMP8 and MMP13 specifically. Atherosclerosis . 2009, 204,(1), 26-33.

Hsiang-Hao Hsu et. Al. Mechanisms of angiotensin II signaling on cytoskeleton of podocytes. Journal of Molecular Medicine . 2008, 86,(12), 1379-1394.

Other References

Harmonized Tariff Code
2937.19
TSCA
No
RTECS
BW2165000

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