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130-61-0 - Thioridazine hydrochloride - J60895 - Alfa Aesar

J60895 Thioridazine hydrochloride

CAS Number
130-61-0
Synonyms

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Thioridazine hydrochloride

MDL
MFCD00012655
EINECS
204-992-8

Chemical Properties

Formula
C21H26N2S2•HCl
Formula Weight
407.03
Form
Powder
Melting point
161-163°
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Soluble in water (75 mM), DMSO (100 mM), chloroform, ethanol, and methanol.

Applications

Thioridazine is a piperidine typical antipsychotic drug belonging to the phenothiazine widely used in the treatment of schizophrenia and psychosis. It primary use in medicine was the treatment of schizophrenia.This medication is used to treat certain mental/mood disorders (e.g., schizophrenia). Thioridazine·HCl is a calcium channel protein inhibitor as well as a D2DR/D4DR inhibitor. It is an intercalating agent for analyzing the integrity of double stranded DNA by using the square-wave voltammetry.

Notes

Light Sensitive & Hygroscopic. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, light, water, moisture.

Literature References

H. Garfield Kelly,; J. E. Fay,; S. G. Laverty.Thioridazine Hydrochloride (Mellaril): Its Effect on the Electrocardiogram and a Report of Two Fatalities with Electrocardiographic Abnormalities. Can Med Assoc J. 1963, 89 (11), 546-554.

John R. Huston, MD; George E. Bell, MD.The Effect of Thioridazine Hydrochloride and Chlorpromazine on the Electrocardiogram. JAMA. 1966, 198 (1), 16-20..

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9359
Hazard Class
9
Packing Group
III
Harmonized Tariff Code
2934.30
TSCA
No
RTECS
SP2275000

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