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2068-78-2 - Vincristine sulfate, 98+% - J60907 - Alfa Aesar

J60907 Vincristine sulfate, 98+%

CAS Number
2068-78-2
Synonyms

Size Price ($) Quantity Availability
10mg 132.87
25mg 231.30
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Vincristine sulfate, 98+%

MDL
MFCD00084729
EINECS
218-190-0

Chemical Properties

Formula
C46H58N4O14S
Formula Weight
923.04
Form
Powder
Melting point
>300°
Boiling Point
273-281°
Solubility
Soluble in DMSO at 60mg/ml. Soluble in water at 25mg/ml with warming. Very poorly soluble in ethanol

Applications

Vincristine sulfate, is used as an anticancer agent, microtubule disrupter, Induces apoptosis in human lymphoma cells. Other applications include as a cell cycle arresting, apoptotic inducing alkaloid.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents, heavy metal salts.

Literature References

Jordan et al.  Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985, 45  ,(6), 2741-7.

Takano et al. Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 1993, 189 ,(2), 197-203.

GHS Hazard and Precautionary Statements

Hazard Statements: H360-H341

May damage fertility or the unborn child. Suspected of causing genetic defects.

Precautionary Statements: P201-P281-P202-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9986
Beilstein
3924631
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2939.99
TSCA
No
RTECS
OH6340000

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