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1476-53-5 - Novobiocin sodium salt - J60928 - Alfa Aesar

J60928 Novobiocin sodium salt

CAS Number
1476-53-5
Synonyms

Size Price ($) Quantity Availability
1g 33.68
5g 112.27
10g 189.52
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Novobiocin sodium salt

MDL
MFCD00066541
EINECS
216-023-6

Chemical Properties

Formula
C31H35N2NaO11
Formula Weight
634.61
Form
Powder
Melting point
215°
Solubility
Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol.

Applications

Topoisomerase II inhibitorNovobiocin sodium salt is effective an antistaphylococcal agent used in the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). It is also used to inhibit the activity of retroviral RNA-dependent DNA polymerase as well as inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.Incompatible with oxidizing agents.

Literature References

Aguirre-Martínez, G. V.; DelValls, A. T.; Martín-Díaz, M. L. Yes, caffeine, ibuprofen, carbamazepine, novobiocin and tamoxifen have an effect on Corbicula fluminea (Müller, 1774). Ecotox. Environ. Safe. 2015, 120, 142-154.

Rymer, J. K.; Hauser, M.; Bourdon, A. K.; Campagna, S. R.; Naider, F.; Becker, J. M. Novobiocin and peptide analogs of alfa-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p. Biochim. Biophys. Acta 2015, 1848 (4), 916-924.

GHS Hazard and Precautionary Statements

Hazard Statements: H319-H317-H303

Causes serious eye irritation. May cause an allergic skin reaction. May be harmful if swallowed.

Precautionary Statements: P261-P280-P264-P305+P351+P338-P312-P363-P321-P333+P313-P337+P313-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6722
Beilstein
3892910
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
RD5425000

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