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MES is used as a running buffer for resolving very small proteins (ex: 13 kDa) on bis-tris gels. Also used in cation-exchange chromatography and as a biological buffer in plant cell cultures. Used in various protein characterization assays. MES is also useful as a non-coordinating buffer in chemistry involving metal ions, as many common buffers (e.g. phosphate and acetate) readily form coordination complexes. MES only weakly binds Ca, Mg, Mn, and it has negligible binding with Cu(II).
Yutaka ORII,; Masayuki MORITA. Measurement of the pH of Frozen Buffer Solutions by Using pH Indicators. J Biochem . 1977 , 81(1),163-168..