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cAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3?: 5?-cyclic monophosphate. In the presence of adenosine 3?:5?-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3?:5?-cyclic monophosphate, and a catalytic subunit. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3?,5?-cyclic monophosphate.
Alfred G. Gilman. A Protein Binding Assay for Adenosine 3?:5?-Cyclic Monophosphate. PNAS. 1970, 67 (1) , 305-312.
B L Brown,; J D Albano,; R P Ekins,; A M Sgherzi. A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate. Biochem J. . 1971, 121 (3), 561-562..