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54965-24-1 - Tamoxifen citrate - cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene citrate - J60955 - Alfa Aesar

J60955 Tamoxifen citrate

CAS Number
54965-24-1
Synonyms
cis-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene citrate

Size Price ($) Quantity Availability
1g 192.61
5g 468.00
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Tamoxifen citrate

MDL
MFCD00058321
EINECS
259-415-2

Chemical Properties

Formula
C26H29NO.C6H8O7
Formula Weight
563.65
Form
White to off-white powder
Sensitivity
Light Sensitive & Hygroscopic
Solubility
Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0.3 mg/L @ 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/ml @ 37°C)4, acetone ,chloroform,and DMSO(100mM)

Applications

Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literature References

Wakeling et al. Non-steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid.Biochem. 1984, 20,(1), 111-20.

Paul et al. Both the immunosuppressant SR31747 and the antioestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Δ8-Δ7 sterol isomerase. J.Pharmacol.Exp.Ther. 1998, 285,(3), 1296-302.

GHS Hazard and Precautionary Statements

Hazard Statements: H350-H360-H362-H302

May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children. Harmful if swallowed.

Precautionary Statements: P263-P260-P201-P281-P264-P270-P301+P312-P308+P313-P405-P501a

Avoid contact during pregnancy/while nursing. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9048
Harmonized Tariff Code
2922.29
TSCA
No
RTECS
KH2387000

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