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512-04-9 - Diosgenin - 3-beta-Hydroxy-5-spirostene - Nitogenin - J60976 - Alfa Aesar

J60976 Diosgenin

CAS Number
512-04-9
Synonyms
3-beta-Hydroxy-5-spirostene
Nitogenin

Size Price ($) Quantity Availability
5g 34.40
25g 103.00
100g 287.00
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Diosgenin

MDL
MFCD00016887
EINECS
208-134-3

Chemical Properties

Formula
C27H42O3
Formula Weight
414.63
Form
Powder
Melting point
200-206°
Solubility
Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol.

Applications

Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. Diosgenin has been used in traditional medicine as an antihypercholesterolemia, antihypertriacylglycerolemia, antidiabetes and antihyperglycemia agent. Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Pin-Shern Chen,; Yuan-Wei Shih,; Hsiang-Ching Huang,; Hsing-Wen Cheng. Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression. PLoS ONE. 2011, 6 (5), e20164.

Heena J Shah,; Lele SS. Extraction of Diosgenin, a Bioactive Compound from Natural Source Dioscorea alata Var purpurae. Shah and Lele, J Anal Bioanal Techniques. 2014, 3 (4)

Other References

Merck
14,3295
Beilstein
94582
Harmonized Tariff Code
2932.99
TSCA
No
RTECS
WH1450000

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