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Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. Diosgenin has been used in traditional medicine as an antihypercholesterolemia, antihypertriacylglycerolemia, antidiabetes and antihyperglycemia agent. Diosgenin is a steroid sapogenin used in the semi-synthesis of pregnenolone, cortisone, and progesterone. Diosgenin has estrogenic activity and can reduce the level of serum cholesterol.
Pin-Shern Chen,; Yuan-Wei Shih,; Hsiang-Ching Huang,; Hsing-Wen Cheng. Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression. PLoS ONE. 2011, 6 (5), e20164.
Heena J Shah,; Lele SS. Extraction of Diosgenin, a Bioactive Compound from Natural Source Dioscorea alata Var purpurae. Shah and Lele, J Anal Bioanal Techniques. 2014, 3 (4)