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11096-37-0 - Transferrin (Holo), bovine plasma, 98+% - Siderophilin, iron-saturated - HTF bovine native protein - J61046 - Alfa Aesar

J61046 Transferrin (Holo), bovine plasma, 98+%

CAS Number
11096-37-0
Synonyms
Siderophilin, iron-saturated
HTF bovine native protein

Size Price ($) Quantity Availability
1g 135.00
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Transferrin (Holo), bovine plasma, 98+%

MDL
MFCD00131337
EINECS
234-318-8

Chemical Properties

Form
Lyophilized powder
Solubility
Soluble in water (50 mg/ml).

Applications

Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Literature References

Giorgia Salvagiotto; Sarah Burton; Christine A.Daigh; Deepika Rajesh; Igor I.Slukvin; Nicholas J.Seay. A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs. PLoS ONE. 2011, 6,(3), e17829.

 

Francis Biville; Christophe Brezillon; Dario Giorgini; Muhamed-Kheir Taha. Pyrophosphate-mediated iron acquisition from transferrin in Neisseria meningitidis does not require TonB activity. PLoS ONE. 2014, 9,(10), e107612.

Other References

Merck
14,9571
Harmonized Tariff Code
3002.10
TSCA
Yes

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