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Castanospermine, is used as a glycosidase inhibitor and antiinflammatory agent.castanospermine is used to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.
Saul et al. Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 1984, 230,(2), 668-75.
Gruters et al. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature. 1987, 330,(6143), 74-7.
Hazard Statements: H302-H312-H332
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Precautionary Statements: P261-P280h-P304+P340-P301+P312a-P321-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.