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J61072 Colchicine, 98%

CAS Number
64-86-8
Synonyms

Stock No. Size Price ($) Quantity Availability
J61072-ME 500mg 48.40
J61072-03 1g 84.80
J61072-06 5g 296.00
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Colchicine, 98%

MDL
MFCD00078484
EINECS
200-598-5

Chemical Properties

Formula
C22H25NO6
Formula Weight
399.44
Form
Powder
Melting point
ca 150° dec.
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Applications

Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Notes

Light sensitive. Incompatible with oxidizing agents.

Literature References

A.D.Caperta; M.Delgado; F.Ressurreicao; A.Meister; R.N.Jones; W.Viegas; A.Houben. Colchicine-induced polyploidization depends on tubulin polymerization in c-metaphase cells. Protoplasma. 2006, 227,(2-4), 147-153.

 

A.B.Mendes-Bonato; M.Ferrari Felismino; A.M.Souza Kaneshima; C.Pessim; V.Calisto; M.Suely Pagliarini; C.Borges do Valle. Abnormal meiosis in tetraploid genotypes of Brachiaria brizantha (Poaceae) induced by colchicine: its implications for breeding. Journal of Applied Genetics. 2009, 50,(2), 83-87.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H340

Fatal if swallowed. May cause genetic defects.

Precautionary Statements: P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2471
Beilstein
2228813
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2939.80
TSCA
Yes
RTECS
GH0700000

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