Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

64-86-8 - Colchicine, 98% - J61072 - Alfa Aesar

J61072 Colchicine, 98%

CAS Number
64-86-8
Synonyms

Size Price ($) Quantity Availability
500mg 46.10
1g 80.70
5g 269.00
Add to Cart Add to Quote Request View Item

Colchicine, 98%

MDL
MFCD00078484
EINECS
200-598-5

Chemical Properties

Formula
C22H25NO6
Formula Weight
399.44
Form
Powder
Melting point
ca 150° dec.
Sensitivity
Light Sensitive
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Applications

Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Notes

Light sensitive. Incompatible with oxidizing agents.

Literature References

A.D.Caperta; M.Delgado; F.Ressurreicao; A.Meister; R.N.Jones; W.Viegas; A.Houben. Colchicine-induced polyploidization depends on tubulin polymerization in c-metaphase cells. Protoplasma. 2006, 227,(2-4), 147-153.

 

A.B.Mendes-Bonato; M.Ferrari Felismino; A.M.Souza Kaneshima; C.Pessim; V.Calisto; M.Suely Pagliarini; C.Borges do Valle. Abnormal meiosis in tetraploid genotypes of Brachiaria brizantha (Poaceae) induced by colchicine: its implications for breeding. Journal of Applied Genetics. 2009, 50,(2), 83-87.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H340

Fatal if swallowed. May cause genetic defects.

Precautionary Statements: P201-P280-P301+P310a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2471
Beilstein
2228813
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2939.80
TSCA
Yes
RTECS
GH0700000

Recommended

  • A12024

    Guanine, 98%
  • H32730

    4-Methoxy-2-(trifluoromethyl)benzylamine, 97%
  • H51922

    4-(1-Piperidinyl)benzeneboronic acid pinacol ester, 95%
  • H52381

    6-Bromo-1-tetralone, 96%
  • H52456

    4-Benzamidobenzeneboronic acid, 95%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware