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63597-44-4 - 4alpha-Phorbol 12-myristate 13-acetate, 99% - 4alpha-PMA - J61099 - Alfa Aesar

J61099 4alpha-Phorbol 12-myristate 13-acetate, 99%

CAS Number
63597-44-4
Synonyms
4alpha-PMA

Size Price ($) Quantity Availability
1mg 160.00
5mg 540.00
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4alpha-Phorbol 12-myristate 13-acetate, 99%

MDL
MFCD00153860

Chemical Properties

Formula
C36H56O8
Formula Weight
616.83
Form
Powder or film
Sensitivity
Light Sensitive
Solubility
Soluble in DMSO, methanol or ethanol. Dilute stock solution into aqueous medium at final concentrations of ~2-5µM

Applications

4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Notes

Light sensitive. Incompatible with oxidizing agents and heat.

Literature References

R.A.Nichols; J.W.Haycock; J.K.Wang; P.Greengard. Phorbol ester enhancement of neurotransmitter release from rat brain synaptosomes. Journal of Neurochemistry. 1987, 48,(2), 615-621.

 

S.M.Fischer; K.E.Patrick; M.L.Lee; G.S.Cameron. 4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms. Cancer Research. 1991, 51,(3), 850-856.

Other References

Merck
14,7332
Harmonized Tariff Code
2915.90
TSCA
No

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