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58970-76-6 - Bestatin - Ubenimex - N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutanoyl]-L-leucine - J61106 - Alfa Aesar

J61106 Bestatin

CAS Number
58970-76-6
Synonyms
Ubenimex
N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutanoyl]-L-leucine

Size Price ($) Quantity Availability
100mg 76.50
250mg 153.00
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Bestatin

MDL
MFCD00083262
EINECS
261-529-2

Chemical Properties

Formula
C16H24N2O4
Formula Weight
308.37
Form
Powder
Melting point
233-236°
Solubility
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.

Applications

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Umezawa et al. Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 1976, 29,(1), 97-9.

Imamura and Kimura. Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma . 2000, 37,(5-6), 663-7.

Other References

Merck
14,9842
Harmonized Tariff Code
2924.29
TSCA
No
RTECS
OH2915000

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