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357-57-3 - Brucine - 10,11-Dimethoxystrychnine - J61178 - Alfa Aesar

J61178 Brucine

CAS Number
357-57-3
Synonyms
10,11-Dimethoxystrychnine

Size Price ($) Quantity Availability
5g 24.50
25g 64.20
100g 215.00
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Brucine

MDL
MFCD00005942
EINECS
206-614-7

Chemical Properties

Formula
C23H26N2O4
Formula Weight
394.47
Form
Powder
Melting point
175-178° dec.
Solubility
Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol

Applications

Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Agrawal SS et al. Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line Life Sci. 2011, 89,(5-6), 147-58.

Deng X et al. The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway. Toxicol Sci. 2006, 91,(1), 59-69.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H330-H412

Fatal if swallowed. Fatal if inhaled. Harmful to aquatic life with long lasting effects.

Precautionary Statements: P260-P284-P273-P301+P310-P304+P340-P320-P330-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. Avoid release to the environment. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,1455
Beilstein
63046
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2939.99
TSCA
Yes
RTECS
EH8925000

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