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103476-89-7 - Leupeptin hemisulfate - J61188 - Alfa Aesar

J61188 Leupeptin hemisulfate

CAS Number
103476-89-7
Synonyms

Size Price ($) Quantity Availability
25mg 122.57
100mg 298.70
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Leupeptin hemisulfate

MDL
MFCD00037012

Chemical Properties

Formula
C20H38N6O4•0.5H2SO4
Formula Weight
475.59
Form
Powder
Solubility
Soluble in water, ethanol, dimethyl formamide and acetic acid.

Applications

Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.

Notes

Store in a cool place. Incompatible with strong acids and strong bases.

Literature References

Uchikawa, S.; Yoda, M.; Tohmonda, T.; Kanaji, A.; Matsumoto, M.; Toyama, Y.; Horiuchi, K. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine 2015, 71 (2), 238-245.

Solter, P. F.; Oyama, M. A.; Machen, M. C.; Trafny, D. J.; Sisson, D. D. Detection by ELISA of C-terminal proBNP in plasma from cats with cardiomyopathy. Vet. J. 2015, 206 (2), 213-217.

Other References

Harmonized Tariff Code
2925.29
TSCA
No

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