Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.
Uchikawa, S.; Yoda, M.; Tohmonda, T.; Kanaji, A.; Matsumoto, M.; Toyama, Y.; Horiuchi, K. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine 2015, 71 (2), 238-245.
Solter, P. F.; Oyama, M. A.; Machen, M. C.; Trafny, D. J.; Sisson, D. D. Detection by ELISA of C-terminal proBNP in plasma from cats with cardiomyopathy. Vet. J. 2015, 206 (2), 213-217.