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J61246 U0126, 99+%

CAS Number

Stock No. Size Price ($) Quantity Availability
J61246-MB 25mg 171.00
J61246-MC 100mg 306.00
J61246-!H 300mg 637.00
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U0126, 99+%


Chemical Properties

Formula Weight
Storage & Sensitivity
Store at -20°C.
Soluble in DMSO. Poorly soluble in ethanol and water


U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.


U0126 is hygroscopic and photosensitive. Store in a tightly sealed vial and protect from light. Store at -20?C. Solid product is stable 1 year at -20°C.

Literature References

Duncia et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.. Bioorg.Med.Chem.Lett. 1998, 8,(20), 2839-44.

Favata et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 1998, 273,(29), 18623-32.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • L09482

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  • B22470

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  • 44509

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  • B21871

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  • L07468

    2-Chloro-6-fluorocinnamic acid, predominantly trans, 98%

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