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Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.
P.J.Pentikainen; P.J.Neuvonen; C.Backman. Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent. European Journal of Clinical Pharmacology. 1981, 19,(5), 359-365.
H.Kankaanranta; E.Moilanen. Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes. Molecular Pharmacology. 1995, 47,(5), 1006-1013.
Hazard Statements: H301
Toxic if swallowed.
Precautionary Statements: P264-P270-P301+P310a-P321-P405-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER/doctor Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.