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13710-19-5 - Tolfenamic acid, 99+% - 2 (3-Chloro-2-methylanilino)benzoic acid - Clotam - J61256 - Alfa Aesar

J61256 Tolfenamic acid, 99+%

CAS Number
13710-19-5
Synonyms
2 (3-Chloro-2-methylanilino)benzoic acid
Clotam

Size Price ($) Quantity Availability
5g 54.10
10g 102.00
25g 257.00
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Tolfenamic acid, 99+%

MDL
MFCD00133865
EINECS
237-264-3

Chemical Properties

Formula
C14H12ClNO2
Formula Weight
261.70
Form
Crystalline powder
Solubility
Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).

Applications

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

P.J.Pentikainen; P.J.Neuvonen; C.Backman. Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent. European Journal of Clinical Pharmacology. 1981, 19,(5), 359-365.

 

H.Kankaanranta; E.Moilanen. Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes. Molecular Pharmacology. 1995, 47,(5), 1006-1013.

GHS Hazard and Precautionary Statements

Hazard Statements: H301

Toxic if swallowed.

Precautionary Statements: P264-P270-P301+P310a-P321-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER/doctor Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,9513
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2922.49
TSCA
No
RTECS
CB2687500

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