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1263-89-4 - Paromomycin sulfate - J61274 - Alfa Aesar

J61274 Paromomycin sulfate

CAS Number
1263-89-4
Synonyms

Size Price ($) Quantity Availability
1g 27.50
5g 88.50
25g 321.00
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Paromomycin sulfate

MDL
MFCD00079278
EINECS
215-031-7

Chemical Properties

Formula
C23H45N5O14•H2SO4
Formula Weight
713.71
Form
White to off-white powder
Solubility
Soluble in water

Applications

Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

Begley U et al. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-a. EMBO Mol Med . 2013, 5,(3), 366-83.

Goossens J et al. Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin. BMC Vet Res. 2012, 8,(245), 6148-8.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7041
Beilstein
5715182
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
WK2320000

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