It also exhibits antitumor activity in studies on brain tumor cells. Puromycin is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3¢-terminal end of aminoacyl-tRNA. It has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation.
RA Rosson.; BM Tebo.; KH Nealson. Use of poisons in determination of microbial manganese binding rates in seawater. Appl. Environ. Microbiol. 1984, 47,(7), 740-745.
V Nair.; DJ Emanuel. Synthetic design, stereochemistry, and enzymic activity of a reversed aminoacyl nucleoside: an analog of puromycin. J. Am. Chem. Soc. 1977, 99,(5), 1571-1576.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.