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(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinsons disease, Alzheimers disease, Huntingtons disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.
J.W.Tetrud; J.W.Langston. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science. 1989, 245,(4917), 519-522.
E.W.Tsang; C.Hamani; E.Moro; F.Mazzella; U.Saha; A.M.Lozano; M.Hodaie; R.Chuang; T.Steeves; S.Y.Lim; B.Neagu; R.Chen. Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease. Neurology. 2012, 78,(24), 1930-1938.
Hazard Statements: H315-H319
Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse.