I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinsons disease, Alzheimers disease, Huntingtons disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.
J.W.Tetrud; J.W.Langston. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science. 1989, 245,(4917), 519-522.
E.W.Tsang; C.Hamani; E.Moro; F.Mazzella; U.Saha; A.M.Lozano; M.Hodaie; R.Chuang; T.Steeves; S.Y.Lim; B.Neagu; R.Chen. Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease. Neurology. 2012, 78,(24), 1930-1938.
Hazard Statements: H315-H319
Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313
Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: