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14611-52-0 - (R)-(-)-Deprenyl hydrochloride - Selegiline - J61286 - Alfa Aesar

J61286 (R)-(-)-Deprenyl hydrochloride

CAS Number
14611-52-0
Synonyms
Selegiline

Size Price ($) Quantity Availability
250mg 66.40
1g 198.00
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(R)-(-)-Deprenyl hydrochloride

MDL
MFCD00069299

Chemical Properties

Formula
C13H17N•HCl
Formula Weight
223.74
Form
Crystalline Powder
Solubility
Soluble in water at 100mM

Applications

(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

J.W.Tetrud; J.W.Langston. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science. 1989, 245,(4917), 519-522.

 

E.W.Tsang; C.Hamani; E.Moro; F.Mazzella; U.Saha; A.M.Lozano; M.Hodaie; R.Chuang; T.Steeves; S.Y.Lim; B.Neagu; R.Chen. Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease. Neurology. 2012, 78,(24), 1930-1938.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319

Causes skin irritation. Causes serious eye irritation.

Precautionary Statements: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Other References

Merck
14,8428
Harmonized Tariff Code
2921.49
TSCA
No
RTECS
DA0292500

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