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54-25-1 - 6-Azauridine - 6-Azauracil riboside - 2-beta-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione - J61309 - Alfa Aesar

J61309 6-Azauridine

CAS Number
54-25-1
Synonyms
6-Azauracil riboside
2-beta-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione

Size Price ($) Quantity Availability
1g 80.80
5g 236.80
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6-Azauridine

MDL
MFCD00006472
EINECS
200-199-6

Chemical Properties

Formula
C8H11N3O6
Formula Weight
245.19
Form
Powder
Melting point
160-161°
Solubility
It is soluble in water.

Applications

6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C

Literature References

Rada B.; Dragún M. Antiviral action and selectivity of 6-azauridine. Ann N Y Acad Sci. 1977, 284, 410-7.

JM Crance.; N Scaramozzino.; A Jouan.; D Garin. Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses. Antiviral research. 2003, 58, (1), 73-79.

GHS Hazard and Precautionary Statements

Hazard Statements: H351-H302-H312-H332

Suspected of causing cancer. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P201-P261-P280-P281-P304+P340-P301+P312-P312-P363-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,904
Harmonized Tariff Code
2934.99
TSCA
No
RTECS
XY8575000

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