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536-43-6 - Dyclonine hydrochloride - 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone - J61330 - Alfa Aesar

J61330 Dyclonine hydrochloride

CAS Number
536-43-6
Synonyms
1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone

Size Price ($) Quantity Availability
5g 75.90
25g 219.00
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Dyclonine hydrochloride

MDL
MFCD00035386
EINECS
208-633-6

Chemical Properties

Formula
C18H27NO2•HCl
Formula Weight
325.88
Form
Crystalline powder
Melting point
173-178°
Solubility
Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol.

Applications

Dyclonine hydrochloride is used for the temporary relief of the following occasional mouth and throat symptoms: pain, minor irritation, sore mouth and sore throat. It is a sodium channel blocker and a HSP90 chaperone protein inhibitor. It shows local anesthetic effects in vivo and is orally active.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

H.J.Florestano; M.E.Bahler. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. Journal of the American Pharmaceutical Association. 1956, 45,(5), 320-325.

 

D.D.S., R.S.Ping; D.D.S., J.G.White; D.D.S., L.B.Spear. Dyclonine hydrochloride as a topical anesthetic in dentistry: A preliminary report. Oral Surgery, Oral Medicine, Oral Pathology. 1957, 10,(6), 623-626.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H335-H318

Toxic if swallowed. Causes skin irritation. May cause respiratory irritation. Causes serious eye damage.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P310-P362-P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3473
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
UG8750000

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