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49745-95-1 - Dobutamine hydrochloride - J61333 - Alfa Aesar

J61333 Dobutamine hydrochloride

CAS Number
49745-95-1
Synonyms

Size Price ($) Quantity Availability
250mg 78.00
1g 260.59
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Dobutamine hydrochloride

MDL
MFCD00153795
EINECS
256-464-1

Chemical Properties

Formula
C18H23NO3•HCl
Formula Weight
337.85
Form
Off-white to white powder
Melting point
184-186°
Solubility
Soluble in water or ethanol with warming. Also soluble in methanol

Applications

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.

Notes

Solutions oxidize readily at pH greater than 11. Protect solutions from light

Literature References

R.R.Tuttle; J.Mills. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circulation Research. 1975, 36,(1), 185-196.

 

Y.Huang; K.H.Kwok; N.W.Chan; C.W.Lau; Z.Y.Chen. Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery. Clinical and Experimental Pharmacology and Physiology. 1998, 25,(6), 405-411.

GHS Hazard and Precautionary Statements

Hazard Statements: H361-H302-H312-H332

Suspected of damaging fertility or the unborn child. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P201-P261-P280-P281-P304+P340-P301+P312-P312-P363-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3395
Harmonized Tariff Code
2922.29
TSCA
No

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