I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.
R.R.Tuttle; J.Mills. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circulation Research. 1975, 36,(1), 185-196.
Y.Huang; K.H.Kwok; N.W.Chan; C.W.Lau; Z.Y.Chen. Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery. Clinical and Experimental Pharmacology and Physiology. 1998, 25,(6), 405-411.
Hazard Statements: H302+H312+H332-H361
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P202-P264b-P270-P271-P281-P301+P312-P302+P352-P304+P340-P308+P313-P312-P330-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant