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J61336 4-Fluoro-7-nitrobenzofurazan

CAS Number
29270-56-2
Synonyms
NBD-F
4-Fluoro-7-nitro-2,1,3-benzoxadiazole

Stock No. Size Price ($) Quantity Availability
J61336-MC 100mg 388.00
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4-Fluoro-7-nitrobenzofurazan

MDL
MFCD00010196

Chemical Properties

Formula
C6H2FN3O3
Formula Weight
183.10
Form
Powder
Melting point
53-57°
Flash Point
110°(230°F)
Storage & Sensitivity
Ambient temperatures.
Solubility
It is soluble in DMSO, DMF, CH3OH, CH3CN and CHCl3.

Applications

4-Chloro-7-nitrobenzofurazan (NBD-chloride) was used in the following studies, Synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, Synthesis of functionalized hydroxynaphthofurazan, Spectrophotometric and spectrofluorometric determination of clemastine hydrogen fumarate, loratadine, losartan potassium and ramipril in pharmaceutical formulations. Synthesis of 7-nitrobenzofurazan (NBD)-labeled maleimide, via Diels-Alder reaction. NBD-Cl is widely used to label peptides, proteins, drugs and other biomolecules. It is also a popular derivatizing reagent for HPLC analysis

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C Store under inert gas. Moisture sensitive. Keep away from strong bases.

Literature References

P.A.T. Martins et. al. Binding of phospholipids to β-Lactoglobulin and their transfer to lipid bilayers. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2008, 1778, (5), 1308-1315 .

El-Hay Soad S Abd et. Al. Utility of 4-chloro-7-nitrobenzofurazan (NBD-CI) for the Spectrophotometric and spectrofluorometric determination of several antihistamine and antihypertensive drugs. Journal of AOAC International. 2013, 96, (5), 968-975 .

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1077571
Harmonized Tariff Code
2934.99
TSCA
No

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