Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

28643-80-3 - Nigericin sodium salt, 98+% - Antibiotic K178 sodium salt - J61349 - Alfa Aesar

J61349 Nigericin sodium salt, 98+%

CAS Number
28643-80-3
Synonyms
Antibiotic K178 sodium salt

Size Price ($) Quantity Availability
10mg 133.00
Add to Cart Add to Quote Request View Item

Nigericin sodium salt, 98+%

MDL
MFCD00036825

Chemical Properties

Formula
C40H67NaO11
Formula Weight
746.94
Form
Powder
Solubility
Soluble in chloroform, methanol or ethanol

Applications

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents, acids, bases and heat.

Literature References

K.Suzuki; K.Tohda; H.Aruga; M.Matsuzoe; H.Inoue; T.Shirai. Ion-selective electrodes based on natural carboxylic polyether antibiotics. Analytical chemistry. 1988, 60,(17), 1714-1721.

 

Benjamin Rey; Damien Roussel; Caroline Romestaing; Maud Belouze; Jean-Louis Rouanet; Dominique Desplanches; Brigitte Sibille; Stephane Servais; Claude Duchamp. Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria. BMC Physiology. 2010, 10,5.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,6541
Beilstein
3892398
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
QT6840000

Recommended

  • J67410

    Valinomycin, 10 mg/ml in DMSO, sterile-filtered

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware