Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

73573-88-3 - Mevastatin, 98% - J61357 - Alfa Aesar

J61357 Mevastatin, 98%

CAS Number
73573-88-3
Synonyms

Size Price ($) Quantity Availability
5mg 41.20
10mg 71.30
25mg 99.10
Add to Cart Add to Quote Request View Item

Mevastatin, 98%

MDL
MFCD05662341

Chemical Properties

Formula
C23H34O5
Formula Weight
390.52
Form
Crystalline solid
Solubility
Soluble in ethanol at 25 mg/mL and in DMSO at 20mg/ml

Applications

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C

Literature References

C M Shipman et. al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Research. 1998, 58, (23), 5294-5297.

U Laufs and J K Liao. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. Journal of Biological Chemistry. 1998, 273, (37), 24266-24271.

Other References

Merck
14,6164
Beilstein
1269441
Harmonized Tariff Code
2932.20
TSCA
No
RTECS
EK7907100

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware