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104594-70-9 - Phenylethyl 3,4-dihydroxycinnamate, 99+% - 3,4-Dihydroxycinnamic acid phenylethyl ester - Phenylethyl caffeate - J61386 - Alfa Aesar

J61386 Phenylethyl 3,4-dihydroxycinnamate, 99+%

CAS Number
3,4-Dihydroxycinnamic acid phenylethyl ester
Phenylethyl caffeate

Size Price ($) Quantity Availability
250mg 125.00
1g 372.00
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Phenylethyl 3,4-dihydroxycinnamate, 99+%


Chemical Properties

Formula Weight
Crystalline powder
Melting point
Light Sensitive
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.


Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.


Light sensitive. Incompatible with oxidizing agents and heat.

Literature References

M.R.Fesen; Y.Pommier; F.Leteurtre; S.Hiroguchi; J.Yung; K.W.Kohn; Mark R.Fesen; Yves Pommier; Francois Leteurtre; Satoshi Hiroguchi; Jessie Yung; Kurt W.Kohn. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochemical Pharmacology. 1994, 48,(3), 595-608.


Z.S.Zheng; G.Z.Xue; D.Grunberger; J.H.Prystowsky. Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncology Research. 1995, 7,(9), 445-452.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • H37453

    m-Tolylacetyl chloride, 99%
  • L14536

    4-Benzyloxy-3,5-dimethylbenzoic acid, 98+%
  • H31757

    2-(2-Furyl)-1,3-diphenylimidazolidine, 96%
  • H53258

    4-(3,3-Dimethylureido)benzeneboronic acid pinacol ester, 95%
  • 33115

    Al-23 Round Disc Without Hole;OD (mm), 50;Thick (mm), 6

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