Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

104594-70-9 - Phenylethyl 3,4-dihydroxycinnamate, 99+% - 3,4-Dihydroxycinnamic acid phenylethyl ester - Phenylethyl caffeate - J61386 - Alfa Aesar

J61386 Phenylethyl 3,4-dihydroxycinnamate, 99+%

CAS Number
104594-70-9
Synonyms
3,4-Dihydroxycinnamic acid phenylethyl ester
Phenylethyl caffeate

Size Price ($) Quantity Availability
250mg 118.63
1g 335.54
Add to Cart Add to Quote Request View Item

Phenylethyl 3,4-dihydroxycinnamate, 99+%

MDL
MFCD00866470

Chemical Properties

Formula
C17H16O4
Formula Weight
284.31
Form
Crystalline powder
Melting point
127-129°
Sensitivity
Light Sensitive
Solubility
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Applications

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Notes

Light sensitive. Incompatible with oxidizing agents and heat.

Literature References

M.R.Fesen; Y.Pommier; F.Leteurtre; S.Hiroguchi; J.Yung; K.W.Kohn; Mark R.Fesen; Yves Pommier; Francois Leteurtre; Satoshi Hiroguchi; Jessie Yung; Kurt W.Kohn. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochemical Pharmacology. 1994, 48,(3), 595-608.

 

Z.S.Zheng; G.Z.Xue; D.Grunberger; J.H.Prystowsky. Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncology Research. 1995, 7,(9), 445-452.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2918.29
TSCA
No
RTECS
UD3334375

Recommended

  • H31769

    Ethyl 2-aminothiazole-5-carboxylate, 97%
  • 45557

    Mercaptoacetic acid calcium salt trihydrate, 98%
  • J62264

    TRIS, 1.0M buffer soln., pH 6.5, 0.2 micron filtered
  • H55743

    5-Chloro-2-methylbenzothiazole, 98%
  • H32913

    Dimethyl trisulfide, 98%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware