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J61386 Phenylethyl 3,4-dihydroxycinnamate, 98+%

CAS Number
104594-70-9
Synonyms
3,4-Dihydroxycinnamic acid phenylethyl ester
Phenylethyl caffeate

Stock No. Size Price ($) Quantity Availability
J61386-MD 250mg 116.00
J61386-03 1g 347.00
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Phenylethyl 3,4-dihydroxycinnamate, 98+%

MDL
MFCD00866470

Chemical Properties

Formula
C17H16O4
Formula Weight
284.31
Form
Crystalline powder
Melting point
127-129°
Storage & Sensitivity
Store at -20°C. Light Sensitive.
Solubility
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Applications

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Notes

Light sensitive. Incompatible with oxidizing agents and heat.

Literature References

M.R.Fesen; Y.Pommier; F.Leteurtre; S.Hiroguchi; J.Yung; K.W.Kohn; Mark R.Fesen; Yves Pommier; Francois Leteurtre; Satoshi Hiroguchi; Jessie Yung; Kurt W.Kohn. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochemical Pharmacology. 1994, 48,(3), 595-608.

 

Z.S.Zheng; G.Z.Xue; D.Grunberger; J.H.Prystowsky. Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncology Research. 1995, 7,(9), 445-452.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2918.29
TSCA
No
RTECS
UD3334375

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