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Citrate is an intermediate in the TCA cycle and fatty acid synthesis. It is an allosteric modulator of acetyl-CoA carboxylase, the enzyme that regulates the conversion of acetyl-CoA to malonyl-CoA. It has anticoagulant activity and is a calcium chelator. Its function is to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies.
J.Steigman; G.Meinken; P.Richards. The reduction of pertechnetate-99 by stannous chlorideI. The stoichiometry of the reaction in HCl, in a citrate buffer and in a DTPA buffer. The International Journal of Applied Radiation and Isotopes. 1975, 26,(10), 601-609.
M.Seruga; M.Metikos-Hukovic; T.Valla; M.Milun; H.Hoffschultz; K.Wandelt. Electrochemical and X-ray photoelectron spectroscopy studies of passive film on tin in citrate buffer solution. Journal of Electroanalytical Chemistry. 1996, 407,(1-2), 83-89.
Hazard Statements: H318
Causes serious eye damage.
Precautionary Statements: P280i-P305+P351+P338-P310a
Wear eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.