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121268-17-5 - Alendronate sodium trihydrate, 97% - MK-217 - J61397 - Alfa Aesar

J61397 Alendronate sodium trihydrate, 97%

CAS Number
121268-17-5
Synonyms
MK-217

Size Price ($) Quantity Availability
1g 34.00
5g 138.00
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Alendronate sodium trihydrate, 97%

MDL
MFCD01748233

Chemical Properties

Formula
C4H12NaNO7P2•3H2O
Formula Weight
325.12 (271.08anhy)
Form
Solid
Solubility
Soluble in water at 10mg/ml

Applications

Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Literature References

Osama Hussein et. al. Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis. Bone . 2011, 48, (2), 202-211 .

Minakshi Asnani et. al. Ab initio structure determination of anhydrous sodium alendronate from laboratory powder X-ray diffraction data. Journal of Pharmaceutical Sciences. 2009, 98, (6), 2113-2121.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,229
Harmonized Tariff Code
2931.90
TSCA
No
RTECS
SZ6523500

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