Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

144701-48-4 - Telmisartan, 99% - BIBR 277 - 4'-[(1,4'-Dimethyl-2'-n-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]biphenyl-2-carboxylic acid - J61441 - Alfa Aesar

J61441 Telmisartan, 99%

CAS Number
144701-48-4
Synonyms
BIBR 277
4'-[(1,4'-Dimethyl-2'-n-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]biphenyl-2-carboxylic acid

Size Price ($) Quantity Availability
250mg 54.59
1g 163.77
Add to Cart Add to Quote Request View Item

Telmisartan, 99%

MDL
MFCD00918125

Chemical Properties

Formula
C33H30N4O2
Formula Weight
514.62
Form
Powder
Melting point
261-263°
Solubility
Soluble in DMSO (13 mg/ml at 25°C), chloroform, DMF (~1.6 mg/ml), and ethanol (<1 mg/ml at 25°C). Insoluble in water.

Applications

Telmisartan also acts as a partial agonist of PPAR&#947;, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 ?M). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.

Notes

Hygroscopic, -20°C Freezer, Under Inert Atmosphere. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

B Martina.; T Dieterle.; JP Sigle.; C Surber.; E Battegay. Effects of telmisartan and losartan on left ventricular mass in mild-to-moderate hypertension. Cardiology. 2003, 99, (3), 169-170.

AR Zankl.; B Ivandic.; M Andrassy.; HC Volz. Telmisartan improves absolute walking distance and endothelial function in patients with peripheral artery disease. Clinical Research in Cardiology. 2010, 99, (12), 787-794.

Other References

Merck
14,9129
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
DV2037500

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware