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β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Richard P. Ebstein et. al. Are retinoids potential therapeutic agents in disorders of social cognition including autism?. FEBS Letters.2011, 585, (11), 1529-1536.
Xiaoling Li and Nevzat Kazgan. Mammalian sirtuins and energy metabolism. International Journal of Biological Sciences.2011, 7, (5), 575-587.