Eserine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying. This compound has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, this parasympathomimetic compound is reported to cross the blood-brain barrier. It is also used as a veterinary medication.
Nguyen PV.; Aniksztejn L.; Catarsi S.; Drapeau P. Maturation of neuromuscular transmission during early development in zebrafish. J Neurophysiol. 1999, 81, (6), 2852-61.
Tuovinen K.; Kaliste-Korhonen E.; Raushel FM.; Hanninen O. Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology. 1999, 134, (2-3), 169-78.
Hazard Statements: H300-H330
Fatal if swallowed. Fatal if inhaled.
Precautionary Statements: P301+P310a-P304+P340-P320-P330-P405-P501a
IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.