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57-47-6 - Eserine - Physostigmine - J61477 - Alfa Aesar

J61477 Eserine

CAS Number
57-47-6
Synonyms
Physostigmine

Size Price ($) Quantity Availability
100mg 31.83
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Eserine

MDL
MFCD00151090
EINECS
200-332-8

Chemical Properties

Formula
C15H21N3O2
Formula Weight
275.35
Form
Powder
Melting point
102-104°
Sensitivity
Air & Light Sensitive
Solubility
Soluble in water (1:75), alcohol (1:10), chloroform (1:1), ether (1:30), and DMSO.

Applications

Eserine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying. This compound has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, this parasympathomimetic compound is reported to cross the blood-brain barrier. It is also used as a veterinary medication.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Air and light sensitive. Keep away from strong oxidizing agents, metals, strong acids, strong bases.

Literature References

Nguyen PV.; Aniksztejn L.; Catarsi S.; Drapeau P. Maturation of neuromuscular transmission during early development in zebrafish. J Neurophysiol. 1999, 81, (6), 2852-61.

Tuovinen K.; Kaliste-Korhonen E.; Raushel FM.; Hanninen O. Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology. 1999, 134, (2-3), 169-78.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H330

Fatal if swallowed. Fatal if inhaled.

Precautionary Statements: P260-P284-P301+P310-P304+P340-P320-P330-P310-P405-P403+P233-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7384
Beilstein
91230
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2939.99
TSCA
Yes
RTECS
TJ2100000

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