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1397-89-3 - Amphotericin B, Streptomyces nodosus - J61491 - Alfa Aesar

J61491 Amphotericin B, Streptomyces nodosus

CAS Number
1397-89-3
Synonyms

Size Price ($) Quantity Availability
100mg 49.13
1g 138.02
5g 458.40
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Amphotericin B, Streptomyces nodosus

MDL
MFCD00877763
EINECS
215-742-2

Chemical Properties

Formula
C47H73NO17
Formula Weight
924.10
Form
Powder
Sensitivity
Moisture & Light Sensitive
Solubility
Soluble in aqueous buffers at pH 2.0 or 11.0. Insoluble at pH 6.0-7.0. Also soluble in DMSO or DMF

Applications

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

David R Boulware et. al. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. New England Journal of Medicine. 2014, 370, (26), 2487-2498.

Susobhan Sarkar et. al. Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nature Neuroscience. 2014, 17, (1), 46-55.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,585
Beilstein
78342
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
BU2625000

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