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J61491 Amphotericin B, Streptomyces nodosus

CAS Number
1397-89-3
Synonyms

Stock No. Size Price ($) Quantity Availability
J61491-MC 100mg 51.20
J61491-03 1g 148.00
J61491-06 5g 632.00
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Amphotericin B, Streptomyces nodosus

MDL
MFCD00877763
EINECS
215-742-2

Chemical Properties

Formula
C47H73NO17
Formula Weight
924.10
Form
Powder
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Light Sensitive.
Solubility
Soluble in aqueous buffers at pH 2.0 or 11.0. Insoluble at pH 6.0-7.0. Also soluble in DMSO or DMF

Applications

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.

Notes

Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Literature References

David R Boulware et. al. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. New England Journal of Medicine. 2014, 370, (26), 2487-2498.

Susobhan Sarkar et. al. Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nature Neuroscience. 2014, 17, (1), 46-55.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,585
Beilstein
78342
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
BU2625000

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