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Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.
Chen et al. Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 2002, 16, (21), 2743-8.
D'Amour et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat.Biotechnol. 2006, 24, (11), 1392-401.
Hazard Statements: H341-H361
Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.