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4449-51-8 - Cyclopamine, 99% - 11-Deoxyjervine - J61528 - Alfa Aesar

J61528 Cyclopamine, 99%

CAS Number
4449-51-8
Synonyms
11-Deoxyjervine

Size Price ($) Quantity Availability
25mg 255.00
50mg 452.00
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Cyclopamine, 99%

MDL
MFCD01735266

Chemical Properties

Formula
C27H41NO2
Formula Weight
411.62
Form
Powder
Melting point
234-237°
Solubility
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.

Applications

Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literature References

Chen et al. Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 2002, 16, (21), 2743-8.

D'Amour et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat.Biotechnol. 2006, 24, (11), 1392-401.

GHS Hazard and Precautionary Statements

Hazard Statements: H341-H361

Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P280-P202-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. Do not handle until all safety precautions have been read and understood. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2932.99
TSCA
No
RTECS
GY0750000

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