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1184986-70-6 - 5,7-Dichlorokynurenic acid sodium salt - 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt - J61567 - Alfa Aesar

J61567 5,7-Dichlorokynurenic acid sodium salt

CAS Number
1184986-70-6
Synonyms
5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt

Size Price ($) Quantity Availability
10mg 134.93
50mg 397.60
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5,7-Dichlorokynurenic acid sodium salt

MDL
MFCD00674925

Chemical Properties

Formula
C10H4Cl2NNaO3
Formula Weight
280.04
Form
Solid
Solubility
Soluble in DMSO. Insoluble in water

Applications

5,7-Dichlorokynurenic acid sodium salt is a potent NMDA receptor glycine site antagonist. It acts as a chemical and organic intermediate.

Notes

May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Protect from light.

Literature References

McNamara D et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett . 1990, 120, (1), 17-20.

Baron BM et al. Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site. Mol Pharmacol . 1990, 38, (4), 554-61.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.49
TSCA
No
RTECS
VB1984600

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