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18172-33-3 - Cyclopiazonic acid, 98% - J61594 - Alfa Aesar

J61594 Cyclopiazonic acid, 98%

CAS Number
18172-33-3
Synonyms

Size Price ($) Quantity Availability
10mg 123.21
50mg 420.80
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Cyclopiazonic acid, 98%

MDL
MFCD00167445

Chemical Properties

Formula
C20H20N2O3
Formula Weight
336.39
Form
Powder
Solubility
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.

Applications

The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Keep in a dry place. Keep away from strong oxidizing agents.

Literature References

Plenge-Tellechea et al. On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid. J.Biol.Chem. 1997, 272, (5), 2794-800.

Soler et al. Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry. 1998, 37, (12) 4266-74.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H361

Fatal if swallowed. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P201-P281-P264-P270-P301+P310-P308+P313-P321-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. Specific treatment (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
UY8587000

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