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4759-48-2 - 13-cis-Retinoic acid - Isotretinoin - J61666 - Alfa Aesar

J61666 13-cis-Retinoic acid

CAS Number
4759-48-2
Synonyms
Isotretinoin

Size Price ($) Quantity Availability
500mg 195.70
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13-cis-Retinoic acid

MDL
MFCD00079542
EINECS
225-296-0

Chemical Properties

Formula
C20H28O2
Formula Weight
300.44
Form
Powder
Melting point
172-175°
Solubility
Soluble in chloroform, dimethyl sulfoxide, water, ethanol, and ether.

Applications

13-cis-Retinoic acid is used to inhibits cell proliferation and induces cell differentiation. 13-cis-Retinoic acid is primarily used in the treatment of severe recalcitrant nodular acne.

Notes

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Guglielmo Dusi.; Valentina Gamba. The treatment of severe cystic acne with 13-cis-retinoic acid, Evaluation of sebum production and the clinical response in a multiple-dose trial. Journal of the American Academy of Dermatology. 1999, 835,(1-2), 243-246.

Lawrence N. Farrell.; John S. Strauss.; Anna M. Stranieri. Assessment of degradation of 18 antibiotics in the Closed Bottle Test. Chemosphere. 1980, 3,(6), 602-611.

GHS Hazard and Precautionary Statements

Hazard Statements: H360-H315-H319-H335

May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P201-P261-P280-P281-P305+P351+P338-P304+P340-P362-P312-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5228
Harmonized Tariff Code
2936.21
TSCA
Yes
RTECS
VH6440000

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