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129-46-4 - Suramin hexasodium salt, 98+% - J61707 - Alfa Aesar

J61707 Suramin hexasodium salt, 98+%

CAS Number
129-46-4
Synonyms

Size Price ($) Quantity Availability
250mg 207.00
500mg 274.00
1g 517.00
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Suramin hexasodium salt, 98+%

MDL
MFCD00210217
EINECS
204-949-3

Chemical Properties

Formula
C51H34N6Na6O23S6
Formula Weight
1429.16
Form
Powder
Solubility
Soluble in water and saline. Sparingly soluble in 95% bethanol

Applications

Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 ?M along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF. It is used as a G protein uncoupler and inhibitor of PDGF, EGF, TGF-β, SIRT1 and SIRT5. It also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Voogd et al. Recent research on the biological activity of suramin. Pharmacol.Rev. < span>1993, 45, (2), 177-203.

Beindl et al. Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. < span>1996, 50, (2), 415-23.

Other References

Merck
14,9006
Beilstein
3694087
Harmonized Tariff Code
2924.29
TSCA
No
RTECS
QM7000000

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