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134036-52-5 - Tyrphostin B42, 99+% - Tyrphostin AG-490 - N-Benzyl-2-(3,4-dihydroxybenzylidene)cyanoacetamide - J61715 - Alfa Aesar

J61715 Tyrphostin B42, 99+%

CAS Number
134036-52-5
Synonyms
Tyrphostin AG-490
N-Benzyl-2-(3,4-dihydroxybenzylidene)cyanoacetamide

Size Price ($) Quantity Availability
25mg 174.00
100mg 321.00
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Tyrphostin B42, 99+%

MDL
MFCD00236452

Chemical Properties

Formula
C17H14N2O3
Formula Weight
294.31
Form
Powder
Melting point
216-220°
Solubility
Soluble in DMSO or ethanol

Applications

Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Richard C.G. Pollok.; Michael J.G. Farthing.; Mona Bajaj-Elliott.; Ian R. Sanderson.; Vincent McDonald. Interferon gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum. Gastroenterology. 2001, 120,(1), 99-107.

Mirjana Poljakovic.; Jens M. Nygren.; Katarina Persson. Signalling pathways regulating inducible nitric oxide synthase expression in human kidney epithelial cells. European Journal of Pharmacology. 2003, 496,(1-3), 21-28.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2926.90
TSCA
No

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