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Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
PA Shore.; A Burkhalter.; VH Cohn. A method for the fluorometric assay of histamine in tissues. JPET. < span>1959, 127, (3), 182-186.
JM Arrang.; M Garbarg.; JC Schwartz. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histaminereceptor. Nature. < span>1983, 302, (3), 832 - 837.
Hazard Statements: H301-H315-H319-H334-H317-H335
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statements: P284-P261-P301+P310a-P305+P351+P338-P405-P501a
Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.