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51-45-6 - Histamine - J61727 - Alfa Aesar

J61727 Histamine

CAS Number
51-45-6
Synonyms

Size Price ($) Quantity Availability
1g 66.10
5g 252.00
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Histamine

MDL
MFCD00005210
EINECS
200-100-6

Chemical Properties

Formula
C5H9N3
Formula Weight
111.15
Form
Powder
Solubility
Soluble in water, alcohol, and hot chloroform.

Applications

Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Hygroscopic. Handle and store under inert gas. Air sensitive.

Literature References

PA Shore.; A Burkhalter.; VH Cohn. A method for the fluorometric assay of histamine in tissues. JPET. < span>1959, 127, (3), 182-186.

JM Arrang.; M Garbarg.; JC Schwartz. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histaminereceptor. Nature. < span>1983, 302, (3), 832 - 837.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H334-H317-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. May cause respiratory irritation.

Precautionary Statements: P284-P261-P301+P310a-P305+P351+P338-P405-P501a

Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4719
Beilstein
2012
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.29
TSCA
Yes
RTECS
MS1050000

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