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In cell culture, polymyxin B sulfate is used as an antibacterial agent to prevent contamination. Polymyxin B sulfate is recommended for use in cell culture applications at 50 mg/L. It is used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins.
RD Leunk.; PT Johnson.; BC David. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J. Med. Microbiol. < span>1988, 26, (2), 93-99.
JB Weinberg, HA Chapman. Characterization of the effects of endotoxin on macrophage tumor cell killing. The Journal of Immunology. < span>1978, 121, (1), 72-80.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P264-P270-P301+P312a-P330-P501a
Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.