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110044-82-1 - Calpain Inhibitor I, 95+% - Ac-LLnL-CHO - ALLN - J61766 - Alfa Aesar

J61766 Calpain Inhibitor I, 95+%

CAS Number
110044-82-1
Synonyms
Ac-LLnL-CHO
ALLN

Size Price ($) Quantity Availability
5mg 73.10
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Calpain Inhibitor I, 95+%

MDL
MFCD00065505

Chemical Properties

Formula
C20H37N3O4
Formula Weight
383.53
Form
Powder
Solubility
Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.

Applications

It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

A. Rami.; J. Krieglstein. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Research. 1993, 609, (1-2), 67-70.

Shawn A. Milligan.; Michael W. Owens.; Matthew B. Grisham. Inhibition of IκB-α and IκB-β Proteolysis by Calpain Inhibitor I Blocks Nitric Oxide Synthesis. Archives of Biochemistry and Biophysics. 1996, 335, (2), 388-395.

Other References

Beilstein
7656053
Harmonized Tariff Code
2924.19
TSCA
No

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