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It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
A. Rami.; J. Krieglstein. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Research. 1993, 609, (1-2), 67-70.
Shawn A. Milligan.; Michael W. Owens.; Matthew B. Grisham. Inhibition of IκB-α and IκB-β Proteolysis by Calpain Inhibitor I Blocks Nitric Oxide Synthesis. Archives of Biochemistry and Biophysics. 1996, 335, (2), 388-395.